Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

Patients with moderate and severe COVID-19 illness had lower levels of glutathione and higher ROS and ROS/GSH ratio in plasma than patients with mild disease, clearly indicating glutathione deficiency and oxidative stress signs in patients with serious disease manifestations. Full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263077/ 

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The Role of Glutathione in Protecting against the Severe Inflammatory Response Triggered by COVID-19 Full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402141/

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Could glutathione depletion be the Trojan horse of COVID-19 mortality? 

This preclinical study shows that GSH depletion may have a central role in COVID-19 mortality and pathophysiology. Therefore, elevating the GSH level in tissues may decrease the severity and mortality rates of COVID-19. 

Full article: https://pubmed.ncbi.nlm.nih.gov/33336769/ 

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Glutathione Supplementation as an Adjunctive Therapy in COVID-19

Full article: https://pubmed.ncbi.nlm.nih.gov/32992775/

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Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Full article: https://pubmed.ncbi.nlm.nih.gov/32322478/